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Enzyme From Wikipedia, the free encyclopedia
In enzymology, an inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) is an enzyme that catalyzes the chemical reaction
inositol tetrakisphosphate 1-kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.1.134 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 3,4,5,6-tetrakisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase. Other names in common use include 1D-myo-inositol-tetrakisphosphate 1-kinase, inositol-trisphosphate 6-kinase, 1D-myo-inositol-trisphosphate 6-kinase, ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase, inositol-trisphosphate 5-kinase, 1D-myo-inositol-trisphosphate 5-kinase, and ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2ODT, 2Q7D, and 2QB5.
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