Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

In enzymology, a nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.28) is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + alpha-D-aldose 1-phosphate ${\displaystyle \rightleftharpoons }$ diphosphate + NDP-hexose

nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase
Identifiers
EC no.	2.7.7.28
CAS no.	37278-26-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are nucleoside triphosphate and alpha-D-aldose 1-phosphate, whereas its two products are diphosphate and NDP-hexose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase. Other names in common use include NDP hexose pyrophosphorylase, hexose 1-phosphate nucleotidyltransferase, hexose nucleotidylating enzyme, nucleoside diphosphohexose pyrophosphorylase, hexose-1-phosphate guanylyltransferase, GTP:alpha-D-hexose-1-phosphate guanylyltransferase, GDP hexose pyrophosphorylase, guanosine diphosphohexose pyrophosphorylase, nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase, and NTP:hexose-1-phosphate nucleotidyltransferase.

References

• Verachtert H, Rodriguez P, Bass ST, Hansen RG (1966). "Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues". J. Biol. Chem. 241 (9): 2007–13. doi:10.1016/S0021-9258(18)96658-5. PMID 5946626.
• Hansen RG, Verachtert H, Rodriguez P, Bass ST (1966). "GDP-hexose pyrophosphorylase from liver". Complex Carbohydrates. Methods in Enzymology. Vol. 8. pp. 269–271. doi:10.1016/0076-6879(66)08048-0. ISBN 978-0-12-181808-1.