Endospore

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Endospore

An endospore is a <a href="/en/Dormancy" title="Dormancy" class="wl">dormant</a>, tough, and non-reproductive structure produced by some <a href="/en/Bacteria" title="Bacteria" class="wl">bacteria</a> in the phylum <a href="/en/Bacillota" title="Bacillota" class="wl">Bacillota</a>.<a href="#cite_note-1" style="counter-reset: mw-Ref 1;">[1]</a><a href="#cite_note-2" style="counter-reset: mw-Ref 2;">[2]</a> The name "endospore" is suggestive of a spore or seed-like form (endo means 'within'), but it is not a true <a href="/en/Spore" title="Spore" class="wl">spore</a> (i.e., not an offspring). It is a stripped-down, dormant form to which the bacterium can reduce itself. Endospore formation is usually triggered by a lack of nutrients, and usually occurs in <a href="/en/Gram-positive_bacteria" title="Gram-positive bacteria" class="wl">gram-positive bacteria</a>. In endospore formation, the bacterium divides within its cell wall, and one side then engulfs the other.<a href="#cite_note-Cornell-3" style="counter-reset: mw-Ref 3;">[3]</a> Endospores enable <a href="/en/Bacteria" title="Bacteria" class="wl">bacteria</a> to lie dormant for extended periods, even centuries. There are many reports of spores remaining viable over 10,000 years, and revival of spores millions of years old has been claimed. There is one report of viable spores of <a href="/en/Virgibacillus_marismortui" title="Virgibacillus marismortui" class="wl">Bacillus marismortui</a> in salt crystals approximately 250 million years old.<a href="#cite_note-4" style="counter-reset: mw-Ref 4;">[4]</a><a href="#cite_note-Ringo2004-5" style="counter-reset: mw-Ref 5;">[5]</a> When the <a href="/en/Environment_(biology)" title="Environment (biology)" class="mw-redirect wl">environment</a> becomes more favorable, the endospore can reactivate itself into a vegetative state. Most types of bacteria cannot change to the endospore form. Examples of bacterial <a href="/en/Species" title="Species" class="wl">species</a> that can form endospores include <a href="/en/Bacillus_cereus" title="Bacillus cereus" class="wl">Bacillus cereus</a>, <a href="/en/Bacillus_anthracis" title="Bacillus anthracis" class="wl">Bacillus anthracis</a>, <a href="/en/Bacillus_thuringiensis" title="Bacillus thuringiensis" class="wl">Bacillus thuringiensis</a>, <a href="/en/Clostridium_botulinum" title="Clostridium botulinum" class="wl">Clostridium botulinum</a>, and <a href="/en/Clostridium_tetani" title="Clostridium tetani" class="wl">Clostridium tetani</a>.<a href="#cite_note-6" style="counter-reset: mw-Ref 6;">[6]</a>

<div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none" about="#mwt1">Protective structure formed by bacteria</div>
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<figure class="mw-default-size wiki-thumb"><a href="/en/File:Bacillus_subtilis_Spore.jpg" class="mw-file-description image media-thumb" data-hash="File:Bacillus_subtilis_Spore.jpg"><img loading="lazy" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7a/Bacillus_subtilis_Spore.jpg/220px-Bacillus_subtilis_Spore.jpg" decoding="async" data-file-width="500" data-file-height="375" data-file-type="bitmap" height="165" width="220" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7a/Bacillus_subtilis_Spore.jpg/330px-Bacillus_subtilis_Spore.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7a/Bacillus_subtilis_Spore.jpg/440px-Bacillus_subtilis_Spore.jpg 2x" alt="Bacillus_subtilis_Spore.jpg"></a><figcaption>An <a href="/en/Endospore_staining" title="Endospore staining" class="wl">endospore stain</a> of the cell <a href="/en/Bacillus_subtilis" title="Bacillus subtilis" class="wl">Bacillus subtilis</a> showing endospores as green and the vegetative cell as red</figcaption></figure>
<figure class="mw-default-size wiki-thumb"><a href="/en/File:Paenibacillus_alvei_endospore_microscope_image.tif" class="mw-file-description image media-thumb" data-hash="File:Paenibacillus_alvei_endospore_microscope_image.tif"><img loading="lazy" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/21/Paenibacillus_alvei_endospore_microscope_image.tif/lossy-page1-220px-Paenibacillus_alvei_endospore_microscope_image.tif.jpg" decoding="async" data-file-width="1417" data-file-height="1017" data-file-type="bitmap" height="158" width="220" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/21/Paenibacillus_alvei_endospore_microscope_image.tif/lossy-page1-330px-Paenibacillus_alvei_endospore_microscope_image.tif.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/21/Paenibacillus_alvei_endospore_microscope_image.tif/lossy-page1-440px-Paenibacillus_alvei_endospore_microscope_image.tif.jpg 2x" alt="lossy-page1-220px-Paenibacillus_alvei_endospore_microscope_image.tif.jpg"></a><figcaption>Phase-bright endospores of <a href="/en/Paenibacillus_alvei" title="Paenibacillus alvei" class="wl">Paenibacillus alvei</a> imaged with phase-contrast microscopy</figcaption></figure>
The endospore consists of the bacterium's <a href="/en/DNA" title="DNA" class="wl">DNA</a>, <a href="/en/Ribosomes" title="Ribosomes" class="mw-redirect wl">ribosomes</a> and large amounts of <a href="/en/Dipicolinic_acid" title="Dipicolinic acid" class="wl">dipicolinic acid</a>. Dipicolinic acid is a spore-specific chemical that appears to help in the ability for endospores to maintain dormancy. This chemical accounts for up to 10% of the spore's dry weight.<a href="#cite_note-Cornell-3" style="counter-reset: mw-Ref 3;">[3]</a>

Endospores can survive without nutrients. They are resistant to <a href="/en/Ultraviolet_radiation" title="Ultraviolet radiation" class="mw-redirect wl">ultraviolet radiation</a>, <a href="/en/Desiccation" title="Desiccation" class="wl">desiccation</a>, high temperature, extreme freezing and chemical <a href="/en/Disinfectants" title="Disinfectants" class="mw-redirect wl">disinfectants</a>. Thermo-resistant endospores were first hypothesized by <a href="/en/Ferdinand_Cohn" title="Ferdinand Cohn" class="wl">Ferdinand Cohn</a> after studying Bacillus subtilis growth on cheese after boiling the cheese. His notion of spores being the reproductive mechanism for the growth was a large blow to the previous suggestions of spontaneous generation. <a href="/en/Astrophysicist" title="Astrophysicist" class="mw-redirect wl">Astrophysicist</a> Steinn Sigurdsson said "There are viable bacterial spores that have been found that are 40 million years old on Earth – and we know they're very hardened to radiation."<a href="#cite_note-BBC-2011-7" style="counter-reset: mw-Ref 7;">[7]</a> Common antibacterial agents that work by destroying vegetative cell walls do not affect endospores. Endospores are commonly found in soil and water, where they may survive for long periods of time. A variety of different microorganisms form "spores" or "cysts", but the endospores of <a href="/en/Bacillota" title="Bacillota" class="wl">low G+C gram-positive bacteria</a> are by far the most resistant to harsh conditions.<a href="#cite_note-Cornell-3" style="counter-reset: mw-Ref 3;">[3]</a>

Some classes of bacteria can turn into exospores, also known as <a href="/en/Microbial_cyst" title="Microbial cyst" class="wl">microbial cysts</a>, instead of endospores. Exospores and endospores are two kinds of "hibernating" or dormant stages seen in some classes of microorganisms.
 <figure class="mw-default-size wiki-thumb"><a href="/en/File:Endospore_Formation.png" class="mw-file-description image media-thumb" data-hash="File:Endospore_Formation.png"><img loading="lazy" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/49/Endospore_Formation.png/220px-Endospore_Formation.png" decoding="async" data-file-width="2156" data-file-height="1210" data-file-type="bitmap" height="123" width="220" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/49/Endospore_Formation.png/330px-Endospore_Formation.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/49/Endospore_Formation.png/440px-Endospore_Formation.png 2x" alt="Endospore_Formation.png"></a><figcaption>Formation of an endospore through the process of sporulation.</figcaption></figure>

An endospore is a dormant, tough, and non-reproductive structure produced by some bacteria in the phylum Bacillota. The endospore consists of the bacterium's DNA, ribosomes and large amounts of dipicolinic acid. Dipicolinic acid is a spore-specific chemical that appears to help in the ability for endospores to maintain dormancy. This chemical accounts for up to 10% of the spore's dry weight. Endospores can survive without nutrients. They are resistant to ultraviolet radiation, desiccation, high temperature, extreme freezing and chemical disinfectants. Thermo-resistant endospores were first hypothesized by Ferdinand Cohn after studying Bacillus subtilis growth on cheese after boiling the cheese. His notion of spores being the reproductive mechanism for the growth was a large blow to the previous suggestions of spontaneous generation. Astrophysicist Steinn Sigurdsson said "There are viable bacterial spores that have been found that are 40 million years old on Earth – and we know they're very hardened to radiation." 