Etacrynic acid
Chemical compound / From Wikipedia, the free encyclopedia
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Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. A con with ethacrynic acid compared to the other loop diuretic drugs such as furosemide is that it has a significantly steep dose-response curve, which means the drug's dosing is very important as small variance in dose can cause a significant difference in the biological response.
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Trade names | Edecrin |
AHFS/Drugs.com | International Drug Names |
MedlinePlus | a682857 |
Routes of administration | Oral, IV |
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Protein binding | > 98% |
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ECHA InfoCard | 100.000.349 |
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Formula | C13H12Cl2O4 |
Molar mass | 303.14 g·mol−1 |
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Unlike the other loop diuretics, etacrynic acid is not a sulfonamide[1] and thus use is not contraindicated in those with sulfa allergies. If a patient with sulfa allergies is in need of a loop diuretic, it is more likely for the physician to prescribe etacrynic acid for this reason.