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Formate dehydrogenase (cytochrome)

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formate dehydrogenase (cytochrome)
EC no.
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a formate dehydrogenase (cytochrome) (EC is an enzyme that catalyzes the chemical reaction

formate + 2 ferricytochrome b1 CO2 + 2 ferrocytochrome b1 + 2 H+

Thus, the two substrates of this enzyme are formate and ferricytochrome b1, whereas its 3 products are CO2, ferrocytochrome b1, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is formate:ferricytochrome-b1 oxidoreductase. Other names in common use include formate dehydrogenase, and formate:cytochrome b1 oxidoreductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.


  • Gale EF (June 1939). "Formic dehydrogenase of Bacterium coli: its inactivation by oxygen and its protection in the bacterial cell". The Biochemical Journal. 33 (6): 1012–27. doi:10.1042/bj0331012. PMC 1264479. PMID 16746983.

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Formate dehydrogenase (cytochrome)
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