
Fructose 2,6-bisphosphate
Chemical compound / From Wikipedia, the free encyclopedia
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Fructose 2,6-bisphosphate, abbreviated Fru-2,6-P2, is a metabolite that allosterically affects the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. [1] Fru-2,6-P2 itself is synthesized and broken down by the bifunctional enzyme phosphofructokinase 2/fructose-2,6-bisphosphatase (PFK-2/FBPase-2).[2]
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Names | |
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IUPAC name
2,6-Di-O-phosphono-β-D-fructofuranose | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
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MeSH | fructose+2,6-bisphosphate |
PubChem CID |
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CompTox Dashboard (EPA) |
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Properties | |
C6H14O12P2 | |
Molar mass | 340.114 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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The synthesis of Fru-2,6-P2 is performed through a bifunctional enzyme containing both PFK-2 and FBPase-2, which is dephosphorylated, allowing the PFK-2 portion to phosphorylate fructose 6-phosphate using ATP. The breakdown of Fru-2,6-P2 is catalyzed by the phosphorylation of the bifunctional enzyme, which allows FBPase-2 to dephosphorylate fructose 2,6-bisphosphate to produce fructose 6-phosphate and Pi.[3]