Glutamate racemase
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In enzymology, glutamate racemase (MurI with a capital i) (EC 5.1.1.3) is an enzyme that catalyzes the chemical reaction
- L-glutamate D-glutamate
Glutamate Racemase | |||||||||
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Identifiers | |||||||||
EC no. | 5.1.1.3 | ||||||||
CAS no. | 9024-08-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Hence, this enzyme RacE has one substrate, L-glutamate, and one product, D-glutamate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives, including proline racemase, aspartate racemase, and diaminopimelate epimerase.[1] This enzyme participates in glutamate metabolism that is essential for cell wall biosynthesis in bacteria.[2] Glutamate racemase performs the additional function of gyrase inhibition, preventing gyrase from binding to DNA.[3]
Glutamate racemase (MurI) serves two distinct metabolic functions: primarily, it is a critical enzyme in cell wall biosynthesis,[2] but also plays a role in gyrase inhibition.[3] The ability of glutamate racemase and other proteins to serve two distinct functions is known as "moonlighting".