Goserelin
Chemical compound / From Wikipedia, the free encyclopedia
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Goserelin, sold under the brand name Zoladex among others, is a medication which is used to suppress production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer.[1][2] It is an injectable gonadotropin releasing hormone agonist (GnRH agonist).
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Trade names | Zoladex, others |
Other names | D-Ser(But)6Azgly10-GnRH |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601002 |
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Routes of administration | Implant |
Drug class | GnRH analogue; GnRH agonist; Antigonadotropin |
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Protein binding | 27.3% |
Elimination half-life | 4–5 hours |
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ECHA InfoCard | 100.212.024 |
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Formula | C59H84N18O14 |
Molar mass | 1269.433 g·mol−1 |
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NY (what is this?) (verify) |
Structurally, it is a decapeptide. It is the natural GnRH decapeptide with two substitutions to inhibit rapid degradation.
Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.
It was patented in 1976 and approved for medical use in 1987.[3] It is on the World Health Organization's List of Essential Medicines.[4]