Howel–Evans syndrome
Medical condition / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Howel–Evans syndrome?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
Howel–Evans syndrome is an extremely rare condition involving thickening of the skin in the palms of the hands and the soles of the feet (hyperkeratosis). This familial disease is associated with a high lifetime risk of esophageal cancer. For this reason, it is sometimes known as tylosis with oesophageal cancer (TOC).[1]
Quick Facts Tylosis with esophageal cancer, Specialty ...
Tylosis with esophageal cancer | |
---|---|
Specialty | Medical genetics |
Close
The condition is inherited in an autosomal dominant manner, and it has been linked to a mutation in the RHBDF2 gene. It was first described in 1958.[2]