Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
From Wikipedia, the free encyclopedia
In enzymology, a hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) (EC 6.3.5.9) is an enzyme that catalyzes the chemical reaction
- 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate
Quick Facts a,c-diamide synthase (glutamine-hydrolysing), Identifiers ...
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 6.3.5.9 | ||||||||
CAS no. | 132053-22-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
Close
The four substrates of this enzyme are ATP, hydrogenobyrinic acid, L-glutamine, and H2O; its four products are ADP, phosphate, hydrogenobyrinic acid a,c-diamide, and L-glutamate.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming). This enzyme is also called CobB and is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.