Hyper-IgM syndrome type 1
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Hyper IgM syndrome type 1 (HIGM-1) is the X-linked variant of the hyper IgM syndrome.
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Hyper-IgM syndrome type 1 | |
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This condition is inherited in an X-linked recessive manner | |
Specialty | Hematology |
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The affected individuals are virtually always male, because males only have one X chromosome, received from their mothers. Their mothers are not symptomatic, even though they are carriers of the allele, because the trait is recessive. Male offspring of these women have a 50% chance of inheriting their mother's mutant allele.