Integrin alpha 6From Wikipedia, the free encyclopedia Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. Quick Facts ITGA6, Identifiers ...ITGA6IdentifiersAliasesITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6External IDsOMIM: 147556 MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6 Gene location (Human)Chr.Chromosome 2 (human)[1]Band2q31.1Start172,427,354 bp[1]End172,506,459 bp[1]Gene location (Mouse)Chr.Chromosome 2 (mouse)[2]Band2 C2- C3|2 42.79 cMStart71,575,960 bp[2]End71,688,760 bp[2]RNA expression patternBgeeHumanMouse (ortholog)Top expressed intibial nervesural nervespinal gangliatrigeminal ganglionAchilles tendonrectumpylorusduodenumjejunal mucosagumsTop expressed insciatic nerveepithelium of stomachsecondary oocyteatriumleft lung lobecrypt of lieberkuhn of small intestinepyloric antrumleft colonmolarlacrimal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular function metal ion binding integrin binding protein binding laminin binding neuregulin binding protein-containing complex binding insulin-like growth factor I binding cadherin binding Cellular component integral component of membrane membrane focal adhesion basal part of cell plasma membrane hemidesmosome basement membrane cell surface integrin complex basal plasma membrane basolateral plasma membrane external side of plasma membrane integrin alpha6-beta4 complex filopodium Biological process cellular response to extracellular stimulus hemidesmosome assembly renal system development nail development positive regulation of cell-cell adhesion filopodium assembly negative regulation of extrinsic apoptotic signaling pathway extracellular matrix organization odontogenesis of dentin-containing tooth cell-substrate adhesion positive regulation of GTPase activity cell adhesion cell adhesion mediated by integrin brown fat cell differentiation positive regulation of apoptotic process cell-substrate junction assembly integrin-mediated signaling pathway positive regulation of phosphorylation cell-matrix adhesion digestive tract development ectodermal cell differentiation leukocyte migration skin development positive regulation of transcription by RNA polymerase II amelogenesis cellular response to organic cyclic compound positive regulation of cell-substrate adhesion positive regulation of cell migration cell-cell adhesion positive regulation of neuron projection development Sources:Amigo / QuickGOOrthologsSpeciesHumanMouseEntrez365516403EnsemblENSG00000091409ENSMUSG00000027111UniProtP23229Q61739RefSeq (mRNA)NM_000210NM_001079818NM_001316306NM_001365529NM_001365530NM_001394928NM_001277970NM_008397RefSeq (protein)NP_000201NP_001073286NP_001303235NP_001352458NP_001352459NP_001264899NP_032423NP_001393187Location (UCSC)Chr 2: 172.43 – 172.51 MbChr 2: 71.58 – 71.69 MbPubMed search[3][4]WikidataView/Edit HumanView/Edit MouseClose
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. Quick Facts ITGA6, Identifiers ...ITGA6IdentifiersAliasesITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6External IDsOMIM: 147556 MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6 Gene location (Human)Chr.Chromosome 2 (human)[1]Band2q31.1Start172,427,354 bp[1]End172,506,459 bp[1]Gene location (Mouse)Chr.Chromosome 2 (mouse)[2]Band2 C2- C3|2 42.79 cMStart71,575,960 bp[2]End71,688,760 bp[2]RNA expression patternBgeeHumanMouse (ortholog)Top expressed intibial nervesural nervespinal gangliatrigeminal ganglionAchilles tendonrectumpylorusduodenumjejunal mucosagumsTop expressed insciatic nerveepithelium of stomachsecondary oocyteatriumleft lung lobecrypt of lieberkuhn of small intestinepyloric antrumleft colonmolarlacrimal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular function metal ion binding integrin binding protein binding laminin binding neuregulin binding protein-containing complex binding insulin-like growth factor I binding cadherin binding Cellular component integral component of membrane membrane focal adhesion basal part of cell plasma membrane hemidesmosome basement membrane cell surface integrin complex basal plasma membrane basolateral plasma membrane external side of plasma membrane integrin alpha6-beta4 complex filopodium Biological process cellular response to extracellular stimulus hemidesmosome assembly renal system development nail development positive regulation of cell-cell adhesion filopodium assembly negative regulation of extrinsic apoptotic signaling pathway extracellular matrix organization odontogenesis of dentin-containing tooth cell-substrate adhesion positive regulation of GTPase activity cell adhesion cell adhesion mediated by integrin brown fat cell differentiation positive regulation of apoptotic process cell-substrate junction assembly integrin-mediated signaling pathway positive regulation of phosphorylation cell-matrix adhesion digestive tract development ectodermal cell differentiation leukocyte migration skin development positive regulation of transcription by RNA polymerase II amelogenesis cellular response to organic cyclic compound positive regulation of cell-substrate adhesion positive regulation of cell migration cell-cell adhesion positive regulation of neuron projection development Sources:Amigo / QuickGOOrthologsSpeciesHumanMouseEntrez365516403EnsemblENSG00000091409ENSMUSG00000027111UniProtP23229Q61739RefSeq (mRNA)NM_000210NM_001079818NM_001316306NM_001365529NM_001365530NM_001394928NM_001277970NM_008397RefSeq (protein)NP_000201NP_001073286NP_001303235NP_001352458NP_001352459NP_001264899NP_032423NP_001393187Location (UCSC)Chr 2: 172.43 – 172.51 MbChr 2: 71.58 – 71.69 MbPubMed search[3][4]WikidataView/Edit HumanView/Edit MouseClose