Ingenol mebutate
Chemical compound / From Wikipedia, the free encyclopedia
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Ingenol mebutate, sold under the brand name Picato, is a substance that is found in the sap of the plant Euphorbia peplus,[1] commonly known as petty spurge, and is an inducer of cell death. This compound was isolated first from this plant in 2000.[2] A gel formulation of the drug has been approved by the U.S. Food and Drug Administration (FDA)[3] and by the European Medicines Agency (EMA)[4] for the topical treatment of actinic keratosis. Two different strengths of the gel have been approved for use on either the face and scalp (0.015%) or the trunk and extremities (0.05%), respectively.[5] In 2020 the drug was withdrawn from the market in the EU.[6]
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Trade names | Picato |
Other names | PEP005, ingenol-3-angelate |
AHFS/Drugs.com | Monograph |
MedlinePlus | a613008 |
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Routes of administration | Topical (gel) |
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Bioavailability | Below detection level |
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ECHA InfoCard | 100.214.695 |
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Formula | C25H34O6 |
Molar mass | 430.541 g·mol−1 |
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