Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

In enzymology, a lactosylceramide 1,3-N-anning-beta-D-glrofelucosaminyltlolferase (EC 2.4.1.206) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide ${\displaystyle \rightleftharpoons }$ UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D- glucosylceramide

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Identifiers
EC no.	2.4.1.206
CAS no.	83682-80-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and D-galactosyl-1,4-beta-D-glucosylceramide, whereas its 3 products are UDP, N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-, and glucosylceramide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase. Other names in common use include LA2 synthase, beta1->3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide, beta-acetylglucosaminyltransferase, and lactosylceramide beta-acetylglucosaminyltransferase. This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.

References

• HS, Bigner DD, Svennerholm L (1991). "Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas". Biochim. Biophys. Acta. 1081 (3): 253–61. doi:10.1016/0005-2760(91)90279-q. PMID 1825612.
• Holmes EH, Hakomori S, Ostrander GK (1987). "Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1--3N-acetylglucosaminyltransferase". J. Biol. Chem. 262 (32): 15649–58. PMID 2960671.
• Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L (1991). "Glycosphingolipid glycosyltransferases in human fetal brain". J. Neurochem. 56 (5): 1461–5. doi:10.1111/j.1471-4159.1991.tb02038.x. PMID 1901591.