Lanosterol 14 alpha-demethylase
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Lanosterol 14α-demethylase?
Summarize this article for a 10 year old
Lanosterol 14α-demethylase (CYP51A1) is the animal version of a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol.[5] The cytochrome P450 isoenzymes are a conserved group of proteins that serve as key players in the metabolism of organic substances and the biosynthesis of important steroids, lipids, and vitamins in eukaryotes.[6] As a member of this family, lanosterol 14α-demethylase is responsible for an essential step in the biosynthesis of sterols. In particular, this protein catalyzes the removal of the C-14α-methyl group from lanosterol.[6] This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell.[6]
Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CYP51A1 | ||||||
Alt. symbols | CYP51, P45014DM | ||||||
NCBI gene | 1595 | ||||||
HGNC | 2649 | ||||||
OMIM | 601637 | ||||||
RefSeq | NM_000786 | ||||||
UniProt | Q16850 | ||||||
Other data | |||||||
EC number | 1.14.14.154 | ||||||
Locus | Chr. 7 q21.2-21.3 | ||||||
|