Lanosterol synthase
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Lanosterol synthase (EC 5.4.99.7) is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol.[5] Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis.[6][7] In humans, lanosterol synthase is encoded by the LSS gene.[8][9]
lanosterol synthase | |||||||||
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Identifiers | |||||||||
EC no. | 5.4.99.7 | ||||||||
CAS no. | 9032-71-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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LSS | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | LSS, OSC, CTRCT44, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase), lanosterol synthase, HYPT14, APMR4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600909 MGI: 1336155 HomoloGene: 37408 GeneCards: LSS | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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In eukaryotes, lanosterol synthase is an integral monotopic protein associated with the cytosolic side of the endoplasmic reticulum.[10] Some evidence suggests that the enzyme is a soluble, non-membrane bound protein in the few prokaryotes that produce it.[11]
Due to the enzyme's role in cholesterol biosynthesis, there is interest in lanosterol synthase inhibitors as potential cholesterol-reducing drugs, to complement existing statins.[12]