Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.[5][6]
Quick Facts LTC4S, Available structures ...
LTC4S |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4JRZ, 2PNO, 2UUH, 2UUI, 3B29, 3HKK, 3LEO, 3PCV, 4J7T, 4J7Y, 4JC7, 4JCZ, 5HV9, 4WAB |
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Identifiers |
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Aliases | LTC4S, entrez:4056, Leukotriene C4 synthase |
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External IDs | OMIM: 246530 MGI: 107498 HomoloGene: 7406 GeneCards: LTC4S |
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Wikidata |
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The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a complex with 5-Lipoxygenase-activating protein. This protein is remotely related to microsomal glutathione S-transferase.