Levomepromazine
Typical antipsychotic medication / From Wikipedia, the free encyclopedia
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Levomepromazine, also known as methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency antipsychotic (approximately half as potent as chlorpromazine) with strong analgesic, hypnotic and antiemetic properties that are primarily used in palliative care.[2][3]
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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Routes of administration | Oral, seldom IM |
Drug class | Typical antipsychotic |
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Bioavailability | ~50–60% |
Metabolism | Hepatic |
Elimination half-life | ~20 hours |
Excretion | In feces and urine (metabolites), unchanged drug only 1% |
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ECHA InfoCard | 100.000.450 |
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Formula | C19H24N2OS |
Molar mass | 328.47 g·mol−1 |
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Serious side effects include tardive dyskinesia, akathisia, abnormalities in the electrical cycle of the heart, low blood pressure and the potentially fatal neuroleptic malignant syndrome.[2][3]
As is typical of phenothiazine antipsychotics, levomepromazine is a "dirty drug", that is, it exerts its effects by blocking a variety of receptors, including adrenergic receptors, dopamine receptors, histamine receptors, muscarinic acetylcholine receptors and serotonin receptors.[2][3]