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In human spaceflight, a life support system is a group of devices that allow a human being to survive in space. US government space agency NASA, and private spaceflight companies use the term environmental control and life support system or the acronym ECLSS when describing these systems for their human spaceflight missions. The life support system may supply air, water and food. It must also maintain the correct body temperature, an acceptable pressure on the body and deal with the body's waste products. Shielding against harmful external influences such as radiation and micro-meteorites may also be necessary. Components of the life support system are life-critical, and are designed and constructed using safety engineering techniques.
A crewmember of typical size requires approximately 5 kilograms (11 lb) of food, water, and oxygen per day to perform standard activities on a space mission, and outputs a similar amount in the form of waste solids, waste liquids, and carbon dioxide. The mass breakdown of these metabolic parameters is as follows: 0.84 kg (1.9 lb) of oxygen, 0.62 kg (1.4 lb) of food, and 3.54 kg (7.8 lb) of water consumed, converted through the body's physiological processes to 0.11 kg (0.24 lb) of solid wastes, 3.89 kg (8.6 lb) of liquid wastes, and 1.00 kg (2.20 lb) of carbon dioxide produced. These levels can vary due to activity level of a specific mission assignment, but must obey the principle of mass balance. Actual water use during space missions is typically double the given value, mainly due to non-biological use (e.g. showering). Additionally, the volume and variety of waste products varies with mission duration to include hair, finger nails, skin flaking, and other biological wastes in missions exceeding one week in length. Other environmental considerations such as radiation, gravity, noise, vibration, and lighting also factor into human physiological response in space, though not with the more immediate effect that the metabolic parameters have.
By reducing or omitting diluents (constituents other than oxygen, e.g., nitrogen and argon) the total pressure can be lowered to a minimum of about 16 kPa. This can lighten spacecraft structures, reduce leaks and simplify the life support system.
However, the elimination of diluent gases substantially increases fire risks, especially in ground operations when for structural reasons the total cabin pressure must exceed the external atmospheric pressure; see Apollo 1. Furthermore, oxygen toxicity becomes a factor at high oxygen concentrations. For this reason, most modern crewed spacecraft use conventional air (nitrogen/oxygen) atmospheres and use pure oxygen only in pressure suits during extravehicular activity where acceptable suit flexibility mandates the lowest inflation pressure possible.
Water is consumed by crew members for drinking, cleaning activities, EVA thermal control, and emergency uses. It must be stored, used, and reclaimed (from waste water) efficiently since no on-site sources currently exist for the environments reached in the course of human space exploration. Future lunar missions may utilise water sourced from polar ices; Mars missions may utilise water from the atmosphere or ice deposits.
All space missions to date have used supplied food. Life support systems could include a plant cultivation system which allows food to be grown within buildings and/or vessels. This would also regenerate water and oxygen. However, no such system has flown in space as yet. Such a system could be designed so that it reuses most (otherwise lost) nutrients. This is done, for example, by composting toilets which reintegrate waste material (excrement) back into the system, allowing the nutrients to be taken up by the food crops. The food coming from the crops is then consumed again by the system's users and the cycle continues.
American Mercury, Gemini and Apollo spacecraft contained 100% oxygen atmospheres, suitable for short duration missions, to minimize weight and complexity.
The Space Shuttle was the first American spacecraft to have an Earth-like atmospheric mixture, comprising 22% oxygen and 78% nitrogen. For the Space Shuttle, NASA includes in the ECLSS category systems that provide both life support for the crew and environmental control for payloads. The Shuttle Reference Manual contains ECLSS sections on: Crew Compartment Cabin Pressurization, Cabin Air Revitalization, Water Coolant Loop System, Active Thermal Control System, Supply and Waste Water, Waste Collection System, Waste Water Tank, Airlock Support, Extravehicular Mobility Units, Crew Altitude Protection System, and Radioisotope Thermoelectric Generator Cooling and Gaseous Nitrogen Purge for Payloads.
The life support system on the Soyuz spacecraft is called the Kompleks Sredstv Obespecheniya Zhiznideyatelnosti (KSOZh). Vostok, Voshkod and Soyuz contained air-like mixtures at approx 101kPa (14.7 psi).
The Paragon Space Development Corporation is developing a plug and play ECLSS called commercial crew transport-air revitalization system (CCT-ARS) for future spacecraft partially paid for using NASA's Commercial Crew Development (CCDev) money.
The CCT-ARS provides seven primary spacecraft life support functions in a highly integrated and reliable system: Air temperature control, Humidity removal, Carbon dioxide removal, Trace contaminant removal, Post-fire atmospheric recovery, Air filtration, and Cabin air circulation.
Space station systems include technology that enables humans to live in space for a prolonged period of time. Such technology includes filtration systems for human waste disposal and air production.
Skylab used 72% oxygen and 28% nitrogen at a total pressure of 5 psi. 
The Salyut and Mir space stations contained an air-like Oxygen and Nitrogen mixture at approximately sea-level pressures of 93.1 kPa (13.5psi) to 129 kPa (18.8 psi) with an Oxygen content of 21% to 40%.
Main article: ISS ECLSS
The life support system for the Bigelow Commercial Space Station is being designed by Bigelow Aerospace in Las Vegas, Nevada. The space station will be constructed of habitable Sundancer and BA 330 expandable spacecraft modules. As of October 2010[update], "human-in-the-loop testing of the environmental control and life support system (ECLSS)" for Sundancer has begun.
Both space suit models currently in use, the U.S. EMU and the Russian Orlan, include Primary Life Support Systems (PLSSs) allowing the user to work independently without an umbilical connection from a spacecraft. A space suit must provide life support, either through an umbilical connection or an independent PLSS.
Natural LSS like the Biosphere 2 in Arizona have been tested for future space travel or colonization. These systems are also known as closed ecological systems. They have the advantage of using solar energy as primary energy only and being independent from logistical support with fuel. Natural systems have the highest degree of efficiency due to integration of multiple functions. They also provide the proper ambience for humans which is necessary for a longer stay in space.
Micro-Ecological Life Support System Alternative (MELiSSA) is a European Space Agency led initiative, conceived as a micro-organisms and higher plants based ecosystem intended as a tool to gain understanding of the behaviour of artificial ecosystems, and for the development of the technology for a future regenerative life support system for long term manned space missions.
CyBLiSS ("Cyanobacterium-Based Life Support Systems") is a concept developed by researchers from several space agencies (NASA, the German Aerospace Center and the Italian Space Agency) which would use cyanobacteria to process resources available on Mars directly into useful products, and into substrates[clarification needed] for other key organisms of Bioregenerative life support system (BLSS). The goal is to make future manned outposts on Mars as independent of Earth as possible (explorers living "off the land"), to reduce mission costs and increase safety. Even though developed independently, CyBLiSS would be complementary to other BLSS projects (such as MELiSSA) as it can connect them to materials found on Mars, thereby making them sustainable and expandable there. Instead of relying on a closed loop, new elements found on site can be brought into the system.
- Bioregenerative life support system (BLSS) – Artificial ecosystem
- Closed ecological system – Ecosystem that does not exchange matter with the exterior
- Chlorella pyrenoidosa
- Effect of spaceflight on the human body
- Environmental control system
- International Conference on Environmental Systems – conference on human spaceflight technology and space human factors
- Primary life support system – life support device for a space suit
- Spacecraft thermal control
- Artificial gravity
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