Limb–girdle muscular dystrophy
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Limb–girdle muscular dystrophy (LGMD) is a genetically heterogeneous group of rare muscular dystrophies that share a set of clinical characteristics.[7] It is characterised by progressive muscle wasting which affects predominantly hip and shoulder muscles.[8] LGMD usually has an autosomal pattern of inheritance. It currently has no known cure or treatment.[3][9]
Quick Facts Other names, Specialty ...
Limb–girdle muscular dystrophy | |
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Other names | Erb's muscular dystrophy[1] |
Protein MYOT (also known as TTID one of the many genes whose mutations are responsible for this condition) | |
Specialty | Neurology, neuromuscular medicine |
Symptoms | Pelvic muscle weakness[2] |
Duration | Lifelong |
Types | 32 types[3] |
Causes | Genetic mutations |
Diagnostic method | Genetic testing, and possibly muscle biopsy[4] |
Differential diagnosis | Muscular dystrophies: Duchenne, Becker, facioscapulohumeral, Emery-Dreifuss; Pompe disease; congenital myasthenic syndrome; motor neuropathy |
Treatment | Occupational Therapy,speech Therapy and physical therapy[5] |
Frequency | 2.27-10 per 100,000[6] |
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LGMD may be triggered or worsened in genetically susceptible individuals by statins, because of their effects on HMG-CoA reductase[10]