Long-chain-fatty-acid—CoA ligase
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The long chain fatty acyl-CoA ligase (or synthetase) is an enzyme (EC 6.2.1.3) of the ligase family that activates the oxidation of complex fatty acids.[2] Long chain fatty acyl-CoA synthetase catalyzes the formation of fatty acyl-CoA by a two-step process proceeding through an adenylated intermediate.[3] The enzyme catalyzes the following reaction,
Quick Facts Identifiers, EC no. ...
Long-chain-fatty-acid—CoA ligase | |||||||||
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Identifiers | |||||||||
EC no. | 6.2.1.3 | ||||||||
CAS no. | 9013-18-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts acyl-CoA synthetase long-chain family member 1, Identifiers ...
acyl-CoA synthetase long-chain family member 1 | |||||||
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Identifiers | |||||||
Symbol | ACSL1 | ||||||
Alt. symbols | FACL2 | ||||||
NCBI gene | 2180 | ||||||
HGNC | 3569 | ||||||
OMIM | 152425 | ||||||
RefSeq | NM_001995 | ||||||
UniProt | P33121 | ||||||
Other data | |||||||
EC number | 6.2.1.3 | ||||||
Locus | Chr. 4 q35 | ||||||
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It is present in all organisms from bacteria to humans. It catalyzes the pre-step reaction for β-oxidation of fatty acids or can be incorporated in phospholipids.