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|Medullary carcinoma of the breast|
This is the only breast cancer associated with a loss of function mutation in BRCA1, and thus the only form associated with a hereditary mutation. It is typically triple-negative and exhibits upregulation of p53.
This is one of five types of epithelial breast cancer: ductal, lobular, medullary, colloid, and tubular.
DCIS is less commonly present, and medullary breast cancer tends to have a pushing, rather than infiltrative, border. The tumour presents as a soft, fleshy mass with a pushing border. Tumours commonly possess mutations of E-cadherin, which results in its overexpression. Strengthened adhesions between tumour cells reduce the frequency of metastasis.
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- Bacus SS, Zelnick CR, Chin DM, et al. (December 1994). "Medullary carcinoma is associated with expression of intercellular adhesion molecule-1. Implication to its morphology and its clinical behavior". Am. J. Pathol. 145 (6): 1337–48. PMC 1887499. PMID 7992839.
- Kuroda H, Tamaru J, Sakamoto G, Ohnisi K, Itoyama S (January 2005). "Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast". Virchows Arch. 446 (1): 10–4. doi:10.1007/s00428-004-1143-9. PMID 15660281.
- Netra SM, Vani BR, Murthy VS (2018). "Cytomorphological Study of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma". J Cytol. 35 (4): 195–198. doi:10.4103/JOC.JOC_160_17. PMC 6210819. PMID 30498288.CS1 maint: multiple names: authors list (link)
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