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Medullary breast carcinoma

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Medullary carcinoma of the breast
SpecialtyOncology, pathology

Medullary breast carcinoma is a rare type of breast cancer[1] that often can be treated successfully. It is relatively circumscribed.[2]

It involves infiltration by lymphocyte[3] (a type of white blood cell) in and around the tumor that can be seen when viewed under a microscope.[citation needed]

This is the only breast cancer associated with a loss of function mutation in BRCA1, and thus the only form associated with a hereditary mutation. It is typically triple-negative and exhibits upregulation of p53.[citation needed]

This is one of five types of epithelial breast cancer: ductal, lobular, medullary, colloid, and tubular.[citation needed]

DCIS is less commonly present, and medullary breast cancer tends to have a pushing, rather than infiltrative, border. The tumour presents as a soft, fleshy mass with a pushing border. Tumours commonly possess mutations of E-cadherin, which results in its overexpression. Strengthened adhesions between tumour cells reduce the frequency of metastasis.[citation needed]

On histopathology, medullary breast carcinoma is characterized by groups of tumor cells with syncytial appearance (that is, seemingly fused cytoplasms, at left). There is typically also a lymphocytic and plasma cell infiltrate (right).[4]
On histopathology, medullary breast carcinoma is characterized by groups of tumor cells with syncytial appearance (that is, seemingly fused cytoplasms, at left). There is typically also a lymphocytic and plasma cell infiltrate (right).[4]

References

  1. ^ Tominaga J, Hama H, Kimura N, Takahashi S (March 2008). "MR imaging of medullary carcinoma of the breast". Eur J Radiol. 70 (3): 525–9. doi:10.1016/j.ejrad.2008.01.044. PMID 18353587.
  2. ^ Bacus SS, Zelnick CR, Chin DM, et al. (December 1994). "Medullary carcinoma is associated with expression of intercellular adhesion molecule-1. Implication to its morphology and its clinical behavior". Am. J. Pathol. 145 (6): 1337–48. PMC 1887499. PMID 7992839.
  3. ^ Kuroda H, Tamaru J, Sakamoto G, Ohnisi K, Itoyama S (January 2005). "Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast". Virchows Arch. 446 (1): 10–4. doi:10.1007/s00428-004-1143-9. PMID 15660281.
  4. ^ Netra SM, Vani BR, Murthy VS (2018). "Cytomorphological Study of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma". J Cytol. 35 (4): 195–198. doi:10.4103/JOC.JOC_160_17. PMC 6210819. PMID 30498288.CS1 maint: multiple names: authors list (link)

 This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".

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Medullary breast carcinoma
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