α-Methyl-p-tyrosine
Chemical compound / From Wikipedia, the free encyclopedia
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α-Methyl-p-tyrosine (AMPT), or simply α-methyltyrosine, also known in its chiral 2-(S) form as metirosine, is a tyrosine hydroxylase enzyme inhibitor and is therefore a drug involved in inhibiting the catecholamine biosynthetic pathway.[1] AMPT inhibits tyrosine hydroxylase whose enzymatic activity is normally regulated through the phosphorylation of different serine residues in regulatory domain sites.[1] Catecholamine biosynthesis starts with dietary tyrosine, which is hydroxylated by tyrosine hydroxylase and it is hypothesized that AMPT competes with tyrosine at the tyrosine-binding site, causing inhibition of tyrosine hydroxylase.[2]
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ECHA InfoCard | 100.010.477 |
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C10H13NO3 | |
Molar mass | 195.218 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It has been used in the treatment of pheochromocytoma.[2] It has been demonstrated to inhibit the production of melanin.[3] It is available as a generic medication.[4]