Monoamine oxidase

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Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group.[1][2] They are found bound to the outer membrane of mitochondria in most cell types of the body. The first such enzyme was discovered in 1928 by Mary Bernheim in the liver and was named tyramine oxidase.[3][4] The MAOs belong to the protein family of flavin-containing amine oxidoreductases.

Quick facts: Monoamine oxidase, Identifiers, Symbol, Pfam,...
Monoamine oxidase
Identifiers
SymbolMAO
PfamPF01593
InterProIPR001613
OPM superfamily119
OPM protein2z5x
Membranome418
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
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Quick facts: monoamine oxidase A, Identifiers, Symbol, NCB...
monoamine oxidase A
Monoamine_oxidase_A_2BXS.png
Ribbon diagram of a monomer of human MAO-A, with FAD and clorgiline bound, oriented as if attached to the outer membrane of a mitochondrion. From PDB: 2BXS.
Identifiers
SymbolMAOA
NCBI gene4128
HGNC6833
OMIM309850
RefSeqNM_000240
UniProtP21397
Other data
LocusChr. X p11.4-p11.3
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StructuresSwiss-model
DomainsInterPro
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Quick facts: monoamine oxidase B, Identifiers, Symbol, NCB...
monoamine oxidase B
MonoamineOxidase-1GOS.png
Ribbon diagram of human MAO-B. From PDB: 1GOS.
Identifiers
SymbolMAOB
NCBI gene4129
HGNC6834
OMIM309860
RefSeqNM_000898
UniProtP27338
Other data
LocusChr. X p11.4-p11.3
Search for
StructuresSwiss-model
DomainsInterPro
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MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate monoamine neurotransmitters. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with monoamine oxidase inhibitors (MAOIs) which block the action of MAOs.[5]