Monoamine oxidase
Family of enzymes / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Monoamine oxidase?
Summarize this article for a 10 years old
Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group.[1][2] They are found bound to the outer membrane of mitochondria in most cell types of the body. The first such enzyme was discovered in 1928 by Mary Bernheim in the liver and was named tyramine oxidase.[3][4] The MAOs belong to the protein family of flavin-containing amine oxidoreductases.
| Monoamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.4.3.4 | ||||||||
| CAS no. | 9001-66-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Monoamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | MAO | ||||||||
| Pfam | PF01593 | ||||||||
| InterPro | IPR001613 | ||||||||
| OPM superfamily | 119 | ||||||||
| OPM protein | 2z5x | ||||||||
| Membranome | 418 | ||||||||
| |||||||||
| monoamine oxidase A | |||||||
|---|---|---|---|---|---|---|---|
 Ribbon diagram of a monomer of human MAO-A, with FAD and clorgiline bound, oriented as if attached to the outer membrane of a mitochondrion. From PDB: 2BXS. | |||||||
| Identifiers | |||||||
| Symbol | MAOA | ||||||
| NCBI gene | 4128 | ||||||
| HGNC | 6833 | ||||||
| OMIM | 309850 | ||||||
| RefSeq | NM_000240 | ||||||
| UniProt | P21397 | ||||||
| Other data | |||||||
| Locus | Chr. X p11.4-p11.3 | ||||||
| |||||||
| monoamine oxidase B | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifiers | |||||||
| Symbol | MAOB | ||||||
| NCBI gene | 4129 | ||||||
| HGNC | 6834 | ||||||
| OMIM | 309860 | ||||||
| RefSeq | NM_000898 | ||||||
| UniProt | P27338 | ||||||
| Other data | |||||||
| Locus | Chr. X p11.4-p11.3 | ||||||
| |||||||
MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate monoamine neurotransmitters. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with monoamine oxidase inhibitors (MAOIs) which block the action of MAOs.[5]