NAD+ synthase
Enzyme / From Wikipedia, the free encyclopedia
In enzymology, a NAD+ synthetase (EC 6.3.1.5) is an enzyme that catalyzes the chemical reaction
- ATP + deamido-NAD+ + NH3 AMP + diphosphate + NAD+
Quick Facts + synthetase, Identifiers ...
NAD+ synthetase | |||||||||
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Identifiers | |||||||||
EC no. | 6.3.1.5 | ||||||||
CAS no. | 9032-69-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are ATP, deamido-NAD+, and NH3, whereas its 3 products are AMP, diphosphate, and NAD+.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthetase). The systematic name of this enzyme class is deamido-NAD+:ammonia ligase (AMP-forming). Other names in common use include NAD+ synthetase, NAD+ synthetase, nicotinamide adenine dinucleotide synthetase, and diphosphopyridine nucleotide synthetase. This enzyme participates in nicotinate and nicotinamide metabolism and nitrogen metabolism.