NAD(P)H dehydrogenase (quinone 1)
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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NAD(P)H dehydrogenase [quinone] 1 is an enzyme that in humans is encoded by the NQO1 gene.[5] This protein-coding gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a 2-electron reductase (enzyme). This FAD-binding protein forms homodimers and performs two-electron reduction of quinones to hydroquinones and of other redox dyes. It has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone.[6] This gene has an important paralog NQO2. This protein is located in the cytosol.[7]
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NQO1 enzyme expression can be induced by dioxin[8] and inhibited by dicoumarol.[9]