reuptake inhibitor of both norepinephrine and dopamine, and a nicotinicacetylcholinereceptor antagonist, and it activates proopiomelanocortin (POMC) neurons
antagonism of nicotinicacetylcholinereceptors (nAchRs). However, it also appears to be a competitive antagonist of GABAA and glycine receptors. As such,
active as NMDA receptor antagonists in comparison, but retain activity as potent antagonists of the α7-nicotinicacetylcholinereceptor. In 2024, norketamine