2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99,[5] is a protein that in humans is encoded by the OXGR1 (also termed GPR99) gene.[6][7][8] Studies indicate that OXGR1 is a receptor for (i.e., binds and is activated by): alpha-ketoglutaric acid (i.e., α-ketoglutaric acid, also termed 2-oxoglutarate); at least three different cysteinyl-containing leukotrienes (CysLTs), leukotriene E4 (LTE4) and, with less potencies, LTC4 and LTD4;[5][9] and itaconate.[10]
Quick Facts Identifiers, Aliases ...
Close