Omptin
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Omptins (EC 3.4.23.49, protease VII, protease A, gene ompT proteins, ompT protease, protein a, Pla, OmpT) are a family of bacterial proteases.[1] They are aspartate proteases, which cleave peptides with the use of a water molecule. Found in the outer membrane of gram-negative enterobacteria such as Shigella flexneri, Yersinia pestis, Escherichia coli, and Salmonella enterica. Omptins consist of a widely conserved beta barrel spanning the membrane with 5 extracellular loops. These loops are responsible for the various substrate specificities. These proteases rely upon binding of lipopolysaccharide for activity.[2]
Quick Facts Identifiers, Symbol ...
Omptin | |||||||||
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Identifiers | |||||||||
Symbol | Omptin | ||||||||
Pfam | PF01278 | ||||||||
Pfam clan | CL0193 | ||||||||
PROSITE | PDOC00657 | ||||||||
MEROPS | A26 | ||||||||
SCOP2 | 1i78 / SCOPe / SUPFAM | ||||||||
OPM superfamily | 27 | ||||||||
OPM protein | 2x55 | ||||||||
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Omptins have been linked to bacterial pathogenesis.[1]