P70-S6 Kinase 1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene.[5][6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway.[7] As the name suggests, its target substrate is the S6 ribosomal protein.[8] Phosphorylation of S6 induces protein synthesis at the ribosome.
The phosphorylation of p70S6K at threonine 389 has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations. However, several recent studies suggest that the activity of p70S6K plays a more positive role in the increase of autophagy.[9][10]