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PAPSS2

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PAPSS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAPSS2, ATPSK2, BCYM4, SK2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
External IDsOMIM: 603005 MGI: 1330223 HomoloGene: 55840 GeneCards: PAPSS2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004670
NM_001015880

NM_001201470
NM_011864
NM_001360403

RefSeq (protein)

NP_001015880
NP_004661
NP_004661.2

NP_001188399
NP_035994
NP_001347332

Location (UCSC)Chr 10: 87.66 – 87.75 MbChr 19: 32.6 – 32.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.[5][6]

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198682 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024899 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62. doi:10.1038/2458. PMID 9771708. S2CID 13108930.
  6. ^ a b "Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2".

Further reading


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PAPSS2
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