Protein phosphatase 2
Class of enzyme complexes / From Wikipedia, the free encyclopedia
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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene.[2][3] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells.[4] Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.
"PP2" redirects here. For the kinase inhibitor, see PP2 (kinase inhibitor). For the movie, see The Pink Panther 2. For the other movie, see Pitch Perfect 2.
Quick Facts Identifiers, Symbol ...
protein phosphatase 2, catalytic subunit, alpha isoform | |||||||
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Identifiers | |||||||
Symbol | PPP2CA | ||||||
NCBI gene | 5515 | ||||||
HGNC | 9299 | ||||||
OMIM | 176915 | ||||||
RefSeq | NM_002715 | ||||||
UniProt | P67775 | ||||||
Other data | |||||||
EC number | 3.1.3.16 | ||||||
Locus | Chr. 5 q23-q31 | ||||||
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Quick Facts Identifiers, Symbol ...
protein phosphatase 2, catalytic subunit, beta isoform | |||||||
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Identifiers | |||||||
Symbol | PPP2CB | ||||||
NCBI gene | 5516 | ||||||
HGNC | 9300 | ||||||
OMIM | 176916 | ||||||
RefSeq | NM_001009552 | ||||||
UniProt | P62714 | ||||||
Other data | |||||||
EC number | 3.1.3.16 | ||||||
Locus | Chr. 8 p12 | ||||||
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