Panobinostat
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Panobinostat, sold under the brand name Farydak, is a medication used for the treatment of multiple myeloma.[2][3] It is a hydroxamic acid[4] and acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor).[5]
Quick Facts Clinical data, Trade names ...
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Trade names | Farydak |
Other names | LBH-589 |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth |
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Bioavailability | 21%[2] |
Protein binding | 90%[2] |
Metabolism | CYP3A (40%), CYP2D6, CYP2C19[2] |
Elimination half-life | 37 hours[2] |
Excretion | Fecal (44–77%), renal (29–51%)[2] |
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ECHA InfoCard | 100.230.582 |
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Formula | C21H23N3O2 |
Molar mass | 349.434 g·mol−1 |
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Panobinostat was approved for medical use in the United States in February 2015,[2][6][7] and in the European Union in August 2015.[3][8] However, in March 2022, it was withdrawn in the United States.[9][10]