Papaverine
Chemical compound / From Wikipedia, the free encyclopedia
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Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasms and vasospasms (especially those involving the intestines, heart, or brain), occasionally in the treatment of erectile dysfunction and acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine and its derivatives (such as codeine).
Quick Facts Clinical data, Pronunciation ...
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Pronunciation | /pəˈpævəriːn/ |
Trade names | Pavabid, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682707 |
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Routes of administration | Oral, intravenous, intramuscular, rectal, intracavernosal |
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Bioavailability | 80% |
Protein binding | ~90% |
Metabolism | Hepatic |
Elimination half-life | 1.5–2 hours |
Excretion | Renal |
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ECHA InfoCard | 100.000.361 |
Chemical and physical data | |
Formula | C20H21NO4 |
Molar mass | 339.391 g·mol−1 |
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In addition to opium, papaverine is purported to be present in high concentrations in star gooseberry.[1]