Phosphoglycerol geranylgeranyltransferase

In enzymology, a phosphoglycerol geranylgeranyltransferase (EC 2.5.1.41) is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate + sn-glyceryl 1-phosphate ${\displaystyle \rightleftharpoons }$ diphosphate + sn-3-O-(geranylgeranyl)glyceryl 1-phosphate

phosphoglycerol geranylgeranyltransferase
Identifiers
EC no.	2.5.1.41
CAS no.	124650-69-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-glyceryl 1-phosphate, whereas its two products are diphosphate and sn-3-O-(geranylgeranyl)glyceryl 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase. Other names in common use include glycerol phosphate geranylgeranyltransferase, geranylgeranyl-transferase, and prenyltransferase.

References

• Zhang DL, Daniels L, Poulter CD (1990). "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction". J. Am. Chem. Soc. 112 (3): 1264–1265. doi:10.1021/ja00159a067.