DNA polymerase I
Family of enzymes / From Wikipedia, the free encyclopedia
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DNA polymerase I (or Pol I) is an enzyme that participates in the process of prokaryotic DNA replication. Discovered by Arthur Kornberg in 1956,[1] it was the first known DNA polymerase (and the first known of any kind of polymerase). It was initially characterized in E. coli and is ubiquitous in prokaryotes. In E. coli and many other bacteria, the gene that encodes Pol I is known as polA. The E. coli Pol I enzyme is composed of 928 amino acids, and is an example of a processive enzyme — it can sequentially catalyze multiple polymerisation steps without releasing the single-stranded template.[2] The physiological function of Pol I is mainly to support repair of damaged DNA, but it also contributes to connecting Okazaki fragments by deleting RNA primers and replacing the ribonucleotides with DNA.
DNA polymerase I | |||||||
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Identifiers | |||||||
Organism | Escherichia coli (str. K-12 substr. MG1655) | ||||||
Symbol | polA | ||||||
Entrez | 948356 | ||||||
PDB | 1DPI | ||||||
RefSeq (Prot) | NP_418300.1 | ||||||
UniProt | P00582 | ||||||
Other data | |||||||
EC number | 2.7.7.7 | ||||||
Chromosome | genome: 4.04 - 4.05 Mb | ||||||
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