Procollagen peptidase
Class of enzymes / From Wikipedia, the free encyclopedia
Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]
Quick Facts Identifiers, Symbol ...
procollagen (type III) N-endopeptidase | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | PCOLN3 | ||||||
Alt. symbols | PRSM1 | ||||||
NCBI gene | 5119 | ||||||
HGNC | 8740 | ||||||
OMIM | 164010 | ||||||
RefSeq | NM_002768 | ||||||
UniProt | Q9HD42 | ||||||
Other data | |||||||
EC number | 3.4.24.14 | ||||||
Locus | Chr. 16 q24.3 | ||||||
|
Close
The enzyme is present in the skin of rats and humans.[2]