Pseudoallergy
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Pseudoallergy, sometimes known as nonallergic hypersensitivity, is a clinical mimic of immediate-type allergic reactions that lacks underlying immunological mechanisms.[1]
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Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), along with certain food ingredients and additives like tartrazine, benzoates, and salicylates, are the most common causes of pseudoallergic reactions. Since these reactions don't require IgE sensitization, they may manifest themselves after only one exposure. Doses-dependent, pseudoallergic reactions typically involve substances that are chemically unrelated.[2]
The lack of information in skin tests and serology makes the diagnosis challenging. Nonallergic hypersensitivity is diagnosed on the basis of a unique clinical pattern, clinical signs, time course, and response to cause elimination. Oral challenge tests can be used to confirm pseudoallergy in the proper clinical setting.[3]