Rifaximin
Antibiotic medication / From Wikipedia, the free encyclopedia
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Rifaximin, is a non-absorbable, broad spectrum antibiotic mainly used to treat travelers' diarrhea. It is based on the rifamycin antibiotics family. Since its approval in Italy in 1987, it has been licensed in over more than 30 countries for the treatment of a variety of gastrointestinal diseases like irritable bowel syndrome, and hepatic encephalopathy. It acts by inhibiting RNA synthesis in susceptible bacteria by binding to the RNA polymerase enzyme. This binding blocks translocation, which stops transcription.[4] It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.[5]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Xifaxan, Zaxine, Xifaxanta, Normix, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604027 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | < 0.4% |
Metabolism | Liver |
Elimination half-life | 6 hours |
Excretion | Fecal (97%) |
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ECHA InfoCard | 100.111.624 |
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Formula | C43H51N3O11 |
Molar mass | 785.891 g·mol−1 |
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Melting point | 200 to 205 °C (392 to 401 °F) (dec.) |
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