Rotigotine
Dopamine agonist medication / From Wikipedia, the free encyclopedia
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Rotigotine, sold under the brand name Neupro among others, is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease and restless legs syndrome.[3][4] It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.[3]
Quick Facts Clinical data, Trade names ...
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Trade names | Neupro, Leganto |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607059 |
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Routes of administration | Transdermal patch |
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Bioavailability | 37% (transdermal) |
Protein binding | 92% |
Metabolism | Liver (CYP-mediated) |
Elimination half-life | 5–7 hours |
Excretion | Urine (71%), Feces (23%) |
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ECHA InfoCard | 100.123.257 |
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Formula | C19H25NOS |
Molar mass | 315.48 g·mol−1 |
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Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.[5]