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Safrole is an organic compound with the formula CH2O2C6H3CH2CH=CH2. It is a colorless oily liquid, although impure samples can appear yellow. A member of the phenylpropanoid family of natural products, it is found in sassafras plants, among others. Small amounts are found in a wide variety of plants, where it functions as a natural antifeedant. Ocotea pretiosa, which grows in Brazil, and Sassafras albidum, which grows in eastern North America, are the main natural sources of safrole. It has a characteristic "sweet-shop" aroma.
|Preferred IUPAC name
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||162.188 g·mol−1|
|Melting point||11 °C (52 °F; 284 K)|
|Boiling point||232 to 234 °C (450 to 453 °F; 505 to 507 K)|
|H302, H341, H350|
|P201, P281, P308+P313|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
It is a precursor in the synthesis of the insecticide synergist piperonyl butoxide, the fragrance piperonal via isosafrole, and the empathogenic/entactogenic substance MDMA.