Staphylococcus aureus alpha toxin
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Alpha-toxin, also known as alpha-hemolysin (Hla), is the major cytotoxic agent released by bacterium Staphylococcus aureus and the first identified member of the pore forming beta-barrel toxin family.[1] This toxin consists mostly of beta-sheets (68%) with only about 10% alpha-helices. The hly gene on the S. aureus chromosome encodes the 293 residue protein monomer, which forms heptameric units on the cellular membrane to form a complete beta-barrel pore. This structure allows the toxin to perform its major function, development of pores in the cellular membrane, eventually causing cell death.
Quick Facts Alpha-hemolysin, Identifiers ...
Alpha-hemolysin | |||||||
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Identifiers | |||||||
Organism | Staphylococcus aureus | ||||||
Symbol | hly | ||||||
Alt. symbols | hla, Alpha-toxin | ||||||
PDB | 7AHL | ||||||
UniProt | P09616 | ||||||
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