(ex Burg et al. 1979) Kim and Goodfellow 2002
Streptomyces avermitilis MA-4680
Streptomyces avermectinius Takahashi et al. 2002
The first complete genome sequence of S. avermitilis was completed in 2003. The genome consists of a single chromosome with a linear structure, unlike most bacterial genomes, which exist in the form of circular chromosomes.
Avermectins are industrially derived from the fermentation products of S. avermitilis. Avermectin itself was discovered by the Satoshi Ōmura group and first disclosed in Burg et al. 1979. One of the most widely employed drugs against nematode and arthropod infestations is the avermectin derivative ivermectin, as well as abamectin, a widely used insecticide and antihelmintic.