Metabolite channeling
Mechanism in enzymes / From Wikipedia, the free encyclopedia
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Metabolite channeling[1] is the passing of the intermediary metabolic product of one enzyme directly to another enzyme or active site without its release into solution. When several consecutive enzymes of a metabolic pathway channel substrates between themselves,[2] this is called a metabolon.[3] Channeling can make a metabolic pathway more rapid and efficient than it would be if the enzymes were randomly distributed in the cytosol, or prevent the release of unstable intermediates.[4] It can also protect an intermediate from being consumed by competing reactions catalyzed by other enzymes.