Sulpiride
Atypical antipsychotic / From Wikipedia, the free encyclopedia
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Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic)[10] medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose. It is not approved in the United States, Canada, or Australia. The drug is chemically and clinically similar to amisulpride.
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Trade names | Dogmatil, others |
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Routes of administration | By mouth (tablets, capsules, solution), intramuscular injection |
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Bioavailability | 25–40%[2][3] |
Protein binding | <40%[2] |
Metabolism | Not metabolized;[4][5][6][7][8] 95% is exerted as the unchanged drug[2][4] |
Elimination half-life | 6–8 hours[2][9] |
Excretion | Urine (70–90%),[9][3] Feces.[4] |
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ECHA InfoCard | 100.036.124 |
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Formula | C15H23N3O4S |
Molar mass | 341.43 g·mol−1 |
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