Transcription factor II B
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)[5] and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and provides a platform for PIC formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors. It is encoded by the TFIIB gene,[6][7] and is homologous to archaeal transcription factor B and analogous to bacterial sigma factors.[8]
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