Telcagepant
Chemical compound / From Wikipedia, the free encyclopedia
Telcagepant (INN) (code name MK-0974) is a calcitonin gene-related peptide receptor antagonist which was an investigational drug for the acute treatment and prevention of migraine, developed by Merck & Co.[1]
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Routes of administration | Oral |
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Elimination half-life | 5–8 hours |
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Formula | C26H27F5N6O3 |
Molar mass | 566.533 g·mol−1 |
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In the acute treatment of migraine, it was found to have equal efficacy to rizatriptan[2] and zolmitriptan.[3]
A Phase IIa clinical trial studying telcagepant for the prophylaxis of episodic migraine was stopped on March 26, 2009, after the "identification of two patients with significant elevations in serum transaminases".[4] A memo to study locations stated that telcagepant had preliminarily been reported to increase the hepatic liver enzyme alanine transaminase (ALT) levels in "11 out of 660 randomized (double-blinded) study participants." All study participants were told to stop taking the medication.[5]
In July 2011, Merck announced that it had discontinued development of telcagepant.[6]