Tetanus toxin
Extremely potent neurotoxin / From Wikipedia, the free encyclopedia
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Tetanus toxin (TeNT) is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani[1] in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered. It is also called spasmogenic toxin, tentoxilysin, tetanospasmin or, tetanus neurotoxin. The LD50 of this toxin has been measured to be approximately 2.5–3 ng/kg,[2][3] making it second only to the related botulinum toxin (LD50 2 ng/kg)[4] as the deadliest toxin in the world. However, these tests are conducted solely on mice, which may react to the toxin differently from humans and other animals.
Tetanus toxin | |||||||
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Identifiers | |||||||
Organism | Clostridium tetani E88 | ||||||
Symbol | tetX | ||||||
Entrez | 24255210 | ||||||
RefSeq (Prot) | WP_011100836.1 | ||||||
UniProt | P04958 | ||||||
Other data | |||||||
Chromosome | Genomic: 0.07 - 0.07 Mb | ||||||
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Tentoxilysin | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.24.68 | ||||||||
CAS no. | 107231-12-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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C. tetani also produces the exotoxin tetanolysin, a hemolysin, that causes destruction of tissues.[5]