Thiotepa
Chemical compound / From Wikipedia, the free encyclopedia
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Thiotepa (INN[6]), sold under the brand name Tepadina, is a medication used to treat cancer.[4][5][7]
Quick Facts Clinical data, Trade names ...
Clinical data | |||
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Trade names | Tepadina | ||
AHFS/Drugs.com | Monograph | ||
MedlinePlus | a682821 | ||
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Routes of administration | Intravenous, intracavitary, intravesical | ||
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Metabolism | Liver (CYP2B6, CYP3A) | ||
Elimination half-life | 1.5–4.1 hours | ||
Excretion | Kidney 6 hours for thiotepa 8 hours for TEPA | ||
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ECHA InfoCard | 100.000.124 | ||
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Formula | C6H12N3PS | ||
Molar mass | 189.22 g·mol−1 | ||
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Thiotepa is an organophosphorus compound with the formula (C2H4N)3PS.[8] It is an analog of N,N′,N″-triethylenephosphoramide (TEPA), which contains tetrahedral phosphorus and is structurally akin to phosphate. It is manufactured by heating aziridine with thiophosphoryl chloride.[citation needed]