Tiotixene
Typical antipsychotic medication / From Wikipedia, the free encyclopedia
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Tiotixene, or thiothixene is a typical antipsychotic agent currently sold under the brand name Navane which is predominantly utilised to treat acute and chronic schizophrenia.[2] Beyond its primary indication, it can exhibit a variety of effects common to neuroleptic drugs including anxiolytic, anti-depressive, and anti-aggressive properties.[3]
Clinical data | |
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Trade names | Navane |
Other names | Thiothixene (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682867 |
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Routes of administration | By mouth |
Drug class | Typical antipsychotic |
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Pharmacokinetic data | |
Bioavailability | ~100% |
Metabolism | Hepatic |
Elimination half-life | 10–20 hours |
Excretion | Gastrointernal tract, faeces |
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ECHA InfoCard | 100.233.356 |
Chemical and physical data | |
Formula | C23H29N3O2S2 |
Molar mass | 443.62 g·mol−1 |
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The drug was first synthesized and marketed in 1967 under the pharmaceutical company Pfizer.[2][4][5][6] While the usage of the drug has declined in recent decades, the drug continues to be manufactured and prescribed in the US and Canada.[6]
Being a member of the thioxanthene class, it is chemically related to other typical neuroleptic agents such as chlorprothixene, clopenthixol, flupenthixol, and zuclopenthixol. Tiotixene also shares structural similarities with thioproperazine and pipotiazine, which are members of the phenothiazine class.